Proton Pump Inhibitors vs Histamine-2 Receptor Blockers for Stress Ulcer Prophylaxis in Critically Ill Patients: Issues of Interpretability in Pragmatic Trials

Todd W Rice¹, Sunil Kripalani^{2

3}, Christopher J Lindsell^{3

4}

Affiliations

¹ Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
² Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
³ Center for Clinical Quality and Implementation Research, Vanderbilt University Medical Center, Nashville, Tennessee.
⁴ Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.

Comment

Todd W Rice et al. JAMA. 2020.

. 2020 Feb 18;323(7):611-613.

doi: 10.1001/jama.2019.22436.

Todd W Rice¹, Sunil Kripalani^{2

3}, Christopher J Lindsell^{3

4}

¹ Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
² Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
³ Center for Clinical Quality and Implementation Research, Vanderbilt University Medical Center, Nashville, Tennessee.
⁴ Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.

No abstract available

Comment on

Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial.
PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group; Young PJ, Bagshaw SM, Forbes AB, Nichol AD, Wright SE, Bailey M, Bellomo R, Beasley R, Brickell K, Eastwood GM, Gattas DJ, van Haren F, Litton E, Mackle DM, McArthur CJ, McGuinness SP, Mouncey PR, Navarra L, Opgenorth D, Pilcher D, Saxena MK, Webb SA, Wiley D, Rowan KM. PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group, et al. JAMA. 2020 Feb 18;323(7):616-626. doi: 10.1001/jama.2019.22190. JAMA. 2020. PMID: 31950977 Free PMC article. Clinical Trial.