Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jan;53(1):23-37.
doi: 10.1002/jmri.27058. Epub 2020 Jan 17.

Quantitative Susceptibility Mapping: Technical Considerations and Clinical Applications in Neuroimaging

Selvadasan Vinayagamani  1 , R Sheelakumari  1 , Sekar Sabarish  1 , Santhakumar Senthilvelan  1 , Roopa Ros  2 , Bejoy Thomas  1 , Chandrasekharan Kesavadas  1
Affiliations
Review

Quantitative Susceptibility Mapping: Technical Considerations and Clinical Applications in Neuroimaging

Selvadasan Vinayagamani et al. J Magn Reson Imaging. 2021 Jan.

Abstract

Quantitative susceptibility mapping (QSM) is a novel magnetic resonance imaging (MRI) technique for quantifying the spatial distribution of magnetic susceptibility within an object or tissue. Recently, QSM has been widely used to study various dominant magnetic susceptibility sources in the brain, including iron and calcium. In addition, the method enables mapping of the cerebral metabolic rate of oxygen, which could act as a new metabolic biomarker for diseases that involve disruption of the brain's oxygen supply. Thus, the clinical applications of QSM are wide-reaching and hold great promise as imaging biomarkers for studying several neurological diseases. This review aims to summarize the physical concepts and potential clinical applications of QSM in neuroimaging. EVIDENCE LEVEL: 5 TECHNICAL EFFICACY: Stage 2.

Keywords: clinical applications; iron quantification; quantitative susceptibility mapping; venous oxygen saturation.

PubMed Disclaimer

References

    1. Li L. Magnetic susceptibility quantification for arbitrarily shaped objects in inhomogeneous fields. Magn Reson Med 2001;46:907-916.
    1. Salomir R, de Senneville BD, Moonen CTW. A fast calculation method for magnetic field inhomogeneity due to an arbitrary distribution of bulk susceptibility. Concepts Magn Reson Part B Magn Reson Eng 2003;19B(1):26-34.
    1. Marques JP, Bowtell R. Application of a Fourier-based method for rapid calculation of field inhomogeneity due to spatial variation of magnetic susceptibility. Concepts Magn Reson Part B Magn Reson Eng 2005;25B:65-78.
    1. Liu T, Spincemaille P, de Rochefort L, Kressler B, Wang Y. Calculation of susceptibility through multiple orientation sampling (COSMOS): A method for conditioning the inverse problem from measured magnetic field map to susceptibility source image in MRI. Magn Reson Med 2009;61:196-204.
    1. Shmueli K, de Zwart JA, van Gelderen P, Li TQ, Dodd SJ, Duyn JH. Magnetic susceptibility mapping of brain tissue in vivo using MRI phase data. Magn Reson Med 2009;62:1510-1522.

Publication types

LinkOut - more resources