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. 2020 Jan 9;180(1):208-208.e1.
doi: 10.1016/j.cell.2019.12.011.

SnapShot: Splicing Alterations in Cancer

Mohammad Alinoor Rahman  1 , Adrian R Krainer  1 , Omar Abdel-Wahab  2
Affiliations

SnapShot: Splicing Alterations in Cancer

Mohammad Alinoor Rahman et al. Cell. .

Abstract

RNA splicing, the spliceosome-catalyzed process by which pre-messenger RNA (pre-mRNA) is processed to mature mRNA, is altered in a number of ways in cancer. Tumor-specific splicing alterations are created by mutations that disrupt splicing-regulatory elements within genes and impair splicing recognition or by altering the RNA-binding preferences of individual splicing factors. This SnapShot summarizes our current understanding of splicing-factor alterations in cancers. To view this SnapShot, open or download the PDF.

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