Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Dec 18;104(6):1032-1033.
doi: 10.1016/j.neuron.2019.11.026.

Therapeutic Targeting of mTORC2 in mTORopathies

Brianne Dentel  1 , Christine Ochoa Escamilla  1 , Peter T Tsai  2
Affiliations
Free article
Comment

Therapeutic Targeting of mTORC2 in mTORopathies

Brianne Dentel et al. Neuron. .
Free article

Abstract

Dysregulated mTOR contributes to neurodevelopmental dysfunction. A new study (Chen et al., 2019) demonstrates that suppression of mTORC2, not mTORC1, ameliorates survival, seizures, and abnormal behaviors in a Pten mutant model, highlighting mTORC2 as a potential therapeutic target in mTORopathies.

PubMed Disclaimer

Comment on

MeSH terms

Substances

LinkOut - more resources