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Comment
. 2019 Dec 17;51(6):975-977.
doi: 10.1016/j.immuni.2019.11.012.

Virus-Induced Interferon Regulates the Urea Cycle

Akira Nishio  1 , Barbara Rehermann  2
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Virus-Induced Interferon Regulates the Urea Cycle

Akira Nishio et al. Immunity. .
Free article

Abstract

Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell responses and ameliorating liver injury.

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