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Comment
. 2020 Jan 14;52(1):14-16.
doi: 10.1016/j.immuni.2019.12.013.

Mutant KRAS at the Heart of Tumor Immune Evasion

Febe van Maldegem  1 , Julian Downward  2
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Free article
Comment

Mutant KRAS at the Heart of Tumor Immune Evasion

Febe van Maldegem et al. Immunity. .
Free article

Abstract

In the search for therapeutic combinations for the treatment of cancer, the pairing of targeted inhibitors of oncogenic driver pathways with immunotherapy has largely been overlooked. In Nature, Canon et al. (2019) describe how the novel KRAS-G12C inhibitor AMG 510 can potentiate immune rejection in combination with immune checkpoint blockade.

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  • The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
    Canon J, Rex K, Saiki AY, Mohr C, Cooke K, Bagal D, Gaida K, Holt T, Knutson CG, Koppada N, Lanman BA, Werner J, Rapaport AS, San Miguel T, Ortiz R, Osgood T, Sun JR, Zhu X, McCarter JD, Volak LP, Houk BE, Fakih MG, O'Neil BH, Price TJ, Falchook GS, Desai J, Kuo J, Govindan R, Hong DS, Ouyang W, Henary H, Arvedson T, Cee VJ, Lipford JR. Canon J, et al. Nature. 2019 Nov;575(7781):217-223. doi: 10.1038/s41586-019-1694-1. Epub 2019 Oct 30. Nature. 2019. PMID: 31666701 Clinical Trial.

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