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. 2020 Jan 14;52(1):6-8.
doi: 10.1016/j.immuni.2019.12.015.

Clec2d Joins the Cell Death Sensor Ranks

Carlos Del Fresno  1 , David Sancho  2
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Clec2d Joins the Cell Death Sensor Ranks

Carlos Del Fresno et al. Immunity. .
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Abstract

Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology.

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