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Comment
. 2020 Jan 6;52(1):3-4.
doi: 10.1016/j.devcel.2019.12.013.

When the Family Treasure Is a Doormat

Yukiko M Yamashita  1
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Free article
Comment

When the Family Treasure Is a Doormat

Yukiko M Yamashita. Dev Cell. .
Free article

Abstract

Germ cells carry genetic information to the next generation, necessitating special attention to their genome maintenance. Two new studies in this issue of Developmental Cell (Bhargava et al., 2020; Dokshin et al., 2020) reveal an essential function of germ cell-specific protein GCNA in the genome maintenance of germ cells.

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  • GCNA Preserves Genome Integrity and Fertility Across Species.
    Bhargava V, Goldstein CD, Russell L, Xu L, Ahmed M, Li W, Casey A, Servage K, Kollipara R, Picciarelli Z, Kittler R, Yatsenko A, Carmell M, Orth K, Amatruda JF, Yanowitz JL, Buszczak M. Bhargava V, et al. Dev Cell. 2020 Jan 6;52(1):38-52.e10. doi: 10.1016/j.devcel.2019.11.007. Epub 2019 Dec 12. Dev Cell. 2020. PMID: 31839537 Free PMC article.
  • GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability.
    Dokshin GA, Davis GM, Sawle AD, Eldridge MD, Nicholls PK, Gourley TE, Romer KA, Molesworth LW, Tatnell HR, Ozturk AR, de Rooij DG, Hannon GJ, Page DC, Mello CC, Carmell MA. Dokshin GA, et al. Dev Cell. 2020 Jan 6;52(1):53-68.e6. doi: 10.1016/j.devcel.2019.11.006. Epub 2019 Dec 12. Dev Cell. 2020. PMID: 31839538 Free PMC article.

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