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Comment
. 2020 Jan 7;31(1):8-10.
doi: 10.1016/j.cmet.2019.12.003.

Iron Deficiency Causes Wrinkles in Host-Commensal Relationships

Sara J Clasen  1 , Ruth E Ley  2
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Comment

Iron Deficiency Causes Wrinkles in Host-Commensal Relationships

Sara J Clasen et al. Cell Metab. .
Free article

Abstract

Iron is essential for both the host and its resident microbes, resulting in competition under iron-deficient conditions. However, the molecular details underlying this competition are not fully understood. In this issue, Das et al. (2019) describe how a common gut commensal disrupts the host iron regulatory pathway to prevent uptake when iron is scarce.

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  • Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis.
    Das NK, Schwartz AJ, Barthel G, Inohara N, Liu Q, Sankar A, Hill DR, Ma X, Lamberg O, Schnizlein MK, Arqués JL, Spence JR, Nunez G, Patterson AD, Sun D, Young VB, Shah YM. Das NK, et al. Cell Metab. 2020 Jan 7;31(1):115-130.e6. doi: 10.1016/j.cmet.2019.10.005. Epub 2019 Nov 7. Cell Metab. 2020. PMID: 31708445 Free PMC article.

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