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Comment
. 2019 Dec 11;26(6):703-705.
doi: 10.1016/j.chom.2019.11.010.

HIV Latency: Stochastic across Multiple Scales

Maike M K Hansen  1 , Benjamin Martin  2 , Leor S Weinberger  3
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Free article
Comment

HIV Latency: Stochastic across Multiple Scales

Maike M K Hansen et al. Cell Host Microbe. .
Free article

Abstract

Proviral latency is a major barrier to a cure for HIV. In this issue of Cell Host & Microbe, Hataye et al. (2019) show that reactivation of HIV latency is a non-deterministic, highly stochastic (i.e., noisy) process and propose that stochastic transitions to exponential viral expansion require a critical threshold of virus.

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  • Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread.
    Hataye JM, Casazza JP, Best K, Liang CJ, Immonen TT, Ambrozak DR, Darko S, Henry AR, Laboune F, Maldarelli F, Douek DC, Hengartner NW, Yamamoto T, Keele BF, Perelson AS, Koup RA. Hataye JM, et al. Cell Host Microbe. 2019 Dec 11;26(6):748-763.e20. doi: 10.1016/j.chom.2019.10.006. Epub 2019 Nov 21. Cell Host Microbe. 2019. PMID: 31761718 Free PMC article.

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