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Comment
. 2019 Dec 11;26(6):709-711.
doi: 10.1016/j.chom.2019.11.005.

An RNA Surprise in Bacterial Effector Mechanisms

Milan Gerovac  1 , Jörg Vogel  2
Affiliations
Free article
Comment

An RNA Surprise in Bacterial Effector Mechanisms

Milan Gerovac et al. Cell Host Microbe. .
Free article

Abstract

Bacterial pathogens secrete effector proteins to manipulate host signaling proteins and cellular structures. In this issue of Cell Host & Microbe, Pagliuso et al. (2019) propose an effector mechanism in Listeria monocytogenes whereby an RNA-binding protein associates with bacterial RNA that stimulates RIG-I (retinoic acid inducible gene I)-based innate immunity in the host cytosol.

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  • An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling.
    Pagliuso A, Tham TN, Allemand E, Robertin S, Dupuy B, Bertrand Q, Bécavin C, Koutero M, Najburg V, Nahori MA, Tangy F, Stavru F, Bessonov S, Dessen A, Muchardt C, Lebreton A, Komarova AV, Cossart P. Pagliuso A, et al. Cell Host Microbe. 2019 Dec 11;26(6):823-835.e11. doi: 10.1016/j.chom.2019.10.004. Epub 2019 Nov 21. Cell Host Microbe. 2019. PMID: 31761719 Free PMC article.

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