Emerging from the Shadow of Hemagglutinin: Neuraminidase Is an Important Target for Influenza Vaccination
- PMID: 31951584
- DOI: 10.1016/j.chom.2019.11.006
Emerging from the Shadow of Hemagglutinin: Neuraminidase Is an Important Target for Influenza Vaccination
Abstract
Gilchuk et al. (2019) and Zhu et al. (2019) provide detailed structural information about epitopes on influenza virus N9 neuraminidase and characterize breadth, potency, mechanism of action, and in vivo protective effects of human antibodies targeting these epitopes. The findings highlight the importance of neuraminidase as a target for improved influenza virus vaccines.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
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Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies.Cell Host Microbe. 2019 Dec 11;26(6):729-738.e4. doi: 10.1016/j.chom.2019.10.002. Epub 2019 Nov 19. Cell Host Microbe. 2019. PMID: 31757767 Free PMC article.
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Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice.Cell Host Microbe. 2019 Dec 11;26(6):715-728.e8. doi: 10.1016/j.chom.2019.10.003. Epub 2019 Nov 19. Cell Host Microbe. 2019. PMID: 31757769 Free PMC article.
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