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Comment
. 2020 Jan 2;26(1):2-3.
doi: 10.1016/j.stem.2019.12.002.

No Zones Left Behind: Democratic Hepatocytes Contribute to Liver Homeostasis and Repair

Satdarshan P Monga  1
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No Zones Left Behind: Democratic Hepatocytes Contribute to Liver Homeostasis and Repair

Satdarshan P Monga. Cell Stem Cell. .
Free article

Abstract

Despite minimal turnover, liver cells possess immense regenerative capacity. Some studies suggest existence of a hepatocyte subset with such unique capabilities. However, in the current issue of Cell Stem Cell, three independent studies (Chen et al., 2020; Matsumoto et al., 2020, and Sun et al., 2020) demonstrate an equitable homeostatic and reparative potential of all hepatocytes, irrespective of their lobular location or ploidy status.

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