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Comment
. 2020 Jan 2;26(1):4-6.
doi: 10.1016/j.stem.2019.12.003.

Organoids as Oracles for Precision Medicine in Rectal Cancer

Kevin S Kolahi  1 , Michitaka Nakano  2 , Calvin J Kuo  3
Affiliations
Free article
Comment

Organoids as Oracles for Precision Medicine in Rectal Cancer

Kevin S Kolahi et al. Cell Stem Cell. .
Free article

Abstract

Two recent papers in Cell Stem Cell and Nature Medicine (Yao et al. [2019] and Ganesh et al. [2019]) demonstrate the successful use of rectal cancer patient-derived organoids to predict patient responses to neoadjuvant chemoradiation therapy, paving the way toward a new paradigm for precision medicine.

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  • A rectal cancer organoid platform to study individual responses to chemoradiation.
    Ganesh K, Wu C, O'Rourke KP, Szeglin BC, Zheng Y, Sauvé CG, Adileh M, Wasserman I, Marco MR, Kim AS, Shady M, Sanchez-Vega F, Karthaus WR, Won HH, Choi SH, Pelossof R, Barlas A, Ntiamoah P, Pappou E, Elghouayel A, Strong JS, Chen CT, Harris JW, Weiser MR, Nash GM, Guillem JG, Wei IH, Kolesnick RN, Veeraraghavan H, Ortiz EJ, Petkovska I, Cercek A, Manova-Todorova KO, Saltz LB, Lavery JA, DeMatteo RP, Massagué J, Paty PB, Yaeger R, Chen X, Patil S, Clevers H, Berger MF, Lowe SW, Shia J, Romesser PB, Dow LE, Garcia-Aguilar J, Sawyers CL, Smith JJ. Ganesh K, et al. Nat Med. 2019 Oct;25(10):1607-1614. doi: 10.1038/s41591-019-0584-2. Epub 2019 Oct 7. Nat Med. 2019. PMID: 31591597 Free PMC article.
  • Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer.
    Yao Y, Xu X, Yang L, Zhu J, Wan J, Shen L, Xia F, Fu G, Deng Y, Pan M, Guo Q, Gao X, Li Y, Rao X, Zhou Y, Liang L, Wang Y, Zhang J, Zhang H, Li G, Zhang L, Peng J, Cai S, Hu C, Gao J, Clevers H, Zhang Z, Hua G. Yao Y, et al. Cell Stem Cell. 2020 Jan 2;26(1):17-26.e6. doi: 10.1016/j.stem.2019.10.010. Epub 2019 Nov 21. Cell Stem Cell. 2020. PMID: 31761724

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