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. 2020 Jan;6(1):6-9.
doi: 10.1016/j.trecan.2019.11.001. Epub 2019 Dec 3.

Regulatory Factor X 7 and its Potential Link to Lymphoid Cancers

Berenice A Fischer  1 , Sonia T Chelbi  1 , Greta Guarda  2
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Regulatory Factor X 7 and its Potential Link to Lymphoid Cancers

Berenice A Fischer et al. Trends Cancer. 2020 Jan.

Abstract

Alterations in the Regulatory factor X 7 (RFX7) gene have recurrently been reported in lymphoid cancers. Uncharacterized until recently, this transcription factor regulates genes important for ciliogenesis and for limiting cellular metabolic activity. Here we discuss these observations and conjecture on the links between the reported functions of RFX7 and its potential role in lymphoid cancers, encouraging future studies in these directions.

Keywords: RFX7; ciliogenesis; leukemia; lymphoma; metabolism.

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