Newly Synthesized KRASG12C Mediates Escape from KRASG12C Inhibition
- PMID: 31953242
- DOI: 10.1158/2159-8290.CD-RW2020-010
Newly Synthesized KRASG12C Mediates Escape from KRASG12C Inhibition
Abstract
KRAS G12C-mutant cells treated with KRASG12C inhibitors quickly became either quiescent or resistant.
©2020 American Association for Cancer Research.
Comment on
-
Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition.Nature. 2020 Jan;577(7790):421-425. doi: 10.1038/s41586-019-1884-x. Epub 2020 Jan 8. Nature. 2020. PMID: 31915379 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous