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Comment
. 2020 Feb;30(2):99-100.
doi: 10.1038/s41422-020-0276-y.

New myotonic dystrophy type 1 mouse model

Yunping Lei  1 , Richard H Finnell  2   3
Affiliations
Comment

New myotonic dystrophy type 1 mouse model

Yunping Lei et al. Cell Res. 2020 Feb.
No abstract available

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Figures

Fig. 1
Fig. 1. DM1-related genes in control and case mice and CRISPR-Cas9 edited SC mice.
a DMPK 3′-UTR CTG trinucleotide repeat expansion represses itself, upstream DMWD and downstream SIX5 gene expression, which results in the accumulation of MBNL1 in DMPK mRNA 3′-UTR in DM1 cases. b Single key gene heterozygous SC mice failed to recapitulate the DM1 phenotype. c TKO or QKO heterozygous SC mouse faithfully express the DM1 clinical phenotypes.
See this image and copyright information in PMC

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