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Review
. 2020 Jan 17;22(1):4.
doi: 10.1007/s11920-019-1123-z.

Genetic Intersections of Language and Neuropsychiatric Conditions

Tanner Koomar  1 , Jacob J Michaelson  2
Affiliations
Review

Genetic Intersections of Language and Neuropsychiatric Conditions

Tanner Koomar et al. Curr Psychiatry Rep. .

Abstract

Purpose of review: To better understand the shared basis of language and mental health, this review examines the behavioral and neurobiological features of aberrant language in five major neuropsychiatric conditions. Special attention is paid to genes implicated in both language and neuropsychiatric disorders, as they reveal biological domains likely to underpin the processes controlling both.

Recent findings: Abnormal language and communication are common manifestations of neuropsychiatric conditions, and children with impaired language are more likely to develop psychiatric disorders than their peers. Major themes in the genetics of both language and psychiatry include master transcriptional regulators, like FOXP2; key developmental regulators, like AUTS2; and mediators of neurotransmission, like GRIN2A and CACNA1C.

Keywords: Genetics; Language; Neurodevelopment; Psychiatry.

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References

    1. Genet Epidemiol. 2011 Feb;35(2):125-32 - PubMed
    1. Am J Hum Genet. 2009 Aug;85(2):264-72 - PubMed
    1. Am J Hum Genet. 2008 Jan;82(1):165-73 - PubMed
    1. Res Dev Disabil. 2018 Nov;82:20-26 - PubMed
    1. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Feb;3(2):187-197 - PubMed

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