Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Oct;12(10):1045-1054.
doi: 10.1002/pmrj.12327. Epub 2020 Feb 15.

Orthobiologics for the Hip Region: A Narrative Review

Kelly C McInnis  1 , Eric T Chen  2 , Jonathan T Finnoff  3 , Eugene Y Roh  4 , Joanne Borg Stein  1
Affiliations
Review

Orthobiologics for the Hip Region: A Narrative Review

Kelly C McInnis et al. PM R. 2020 Oct.

Abstract

Management of hip region disorders is challenging. Orthobiologic treatments including platelet rich plasma (PRP), mesenchymal stem cells, and amniotic injectables have gained popularity as promising treatments despite a lack of robust evidence for their effectiveness. We review rationale and current evidence for orthobiologics for three common hip region conditions: hip osteoarthritis, gluteal tendinopathy, and proximal hamstring tendinopathy. Overall, the current state of evidence is extremely limited for orthobiologic treatments and is predominantly relevant to PRP injections. There is currently a lack of data to support the use of mesenchymal stem cells or amniotic injectables in these conditions of the hip.

PubMed Disclaimer

References

    1. AAOS [Internet]. Helping Fractures Heal. https://orthoinfo.aaos.org/en/treatment/helping-fractures-heal-orthobiol.... 2010. Accessed September 2, 2019.
    1. Zhu Y, Yuan M, Meng HY, et al. Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: a review. Osteoarthr Cartil. 2013;21(11):1627-1637.
    1. Zhou Y, Wang JHC. PRP treatment efficacy for tendinopathy: a review of basic science studies. Biomed Res Int. 2016;2016:1-8.
    1. Centeno CJ, Al-Sayegh H, Freeman MD, Smith J, Murrell WD, Bubnov R. A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions. Int Orthop. 2016;40(8):1755-1765.
    1. Hernigou P, Homma Y, Flouzat-Lachaniette C-H, Poignard A, Chevallier N, Rouard H. Cancer risk is not increased in patients treated for orthopaedic diseases with autologous bone marrow cell concentrate. J Bone Joint Surg Am. 2013;95(24):2215-2221.