Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Mar;27(3):224-232.
doi: 10.1111/jvh.13260. Epub 2020 Feb 3.

Insights for clinical diagnostic indicators of virus and host in chronic hepatitis B infection

Qishui Ou  1   2   3 , Jianhui Guo  1   2   3 , Yongbin Zeng  1   2   3 , Huijuan Chen  1   2   3
Affiliations
Review

Insights for clinical diagnostic indicators of virus and host in chronic hepatitis B infection

Qishui Ou et al. J Viral Hepat. 2020 Mar.

Abstract

Covalently closed circular DNA (cccDNA), which is stably present in the nucleus of hepatocytes, is an important indicator for evaluating antiviral efficacy. Since cccDNA quantification requires an invasive procedure, serum biological markers that can effectively reflect the transcriptional activity of intrahepatic virus and the efficacy of treatment are required. Here, from the aspects of virus and host, we outline the focus of clinical research of HBV in recent years, including HBV RNA, empty virus, hepatitis B core-related antigen and changes in the immune response. We briefly discuss their significance in predicting disease activity and monitoring treatment response in chronic hepatitis B. On this basis, some issues worthy of attention in laboratory diagnosis are proposed.

Keywords: HBV RNA; chronic hepatitis B; covalently closed circular DNA; empty virus; laboratory diagnosis.

PubMed Disclaimer

References

REFERENCES

    1. Liver EAftSot. EASL clinical practice guidelines: management of chronic hepatitis B virus infection. J Hepatol. 2012;57(1):167-185.
    1. Liver EAftSot. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection. J Hepatol. 2017;67(2):370-398.
    1. Terrault NA, Bzowej NH, Chang KM, et al. AASLD guidelines for treatment of chronic hepatitis B. Hepatology. 2016;63(1):261-283.
    1. Terrault NA, Lok ASF, McMahon BJ, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018;67(4):1560-1599.
    1. Hepatology CSo. Guidelines for the prevention and treatment of chronic hepatitis B (2015). J Pract Hepatol. 2016;19(3):1-18.

Publication types

LinkOut - more resources