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. 2020 Jan-Mar;9(1):27-29.
doi: 10.4103/sajc.sajc_47_19.

Primary malignant mediastinal germ cell tumors: A single institutional experience

Subhasis Mishra  1 , Saroj Kumar Das Majumdar  1 , Mukund Sable  2 , Dillip Kumar Parida  1
Affiliations

Primary malignant mediastinal germ cell tumors: A single institutional experience

Subhasis Mishra et al. South Asian J Cancer. 2020 Jan-Mar.

Abstract

Background: Primary mediastinal malignant germ cell tumour (PMMGCT) is rare with unsatisfactory prognosis and pose difficulty in management due to lack of guidelines.

Methods: All cases of PMMGCT diagnosed and treated between years 2014 to 2018 were retrospectively evaluated for clinico-pathological features, multimodality treatment and follow up.

Results: Among a total of five PMMGCT cases, three were seminomatous and two were non seminomatous tumour [Yolk- sac tumour (n-1) and Mixed tumour (n-1)]. Four of these cases were non - metastatic with locally advancement and another one presented with metastasis to supraclavicular lymph node. All patients received platinum based induction chemotherapy. Post-induction chemotherapy, two cases of non seminomatous tumours underwent surgery. Among the three seminoma cases, one patient showed complete metabolic response; one with metastasis succumbed to the disease and the in-operable case of seminoma received local radiotherapy.

Conclusion: PMMGCT needs a multi-disciplinary approach for appropriate diagnosis and management. Clinicopathological features like tumour site, extension, histopathological type, tumour stage and serum tumour marker are necessary for prognostication and decision making of further treatment plan.

Keywords: Extragonadal germ cell tumor; mediastinum; multimodality management; seminoma; yolk-sac tumor.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Comparative positron emission tomography-computed tomography scan images in coronal section of a patient showing prechemotherapy disease extent (a) and complete metabolic response after completing chemotherapy (b)
Figure 2
Figure 2
Comparative positron emission tomography-computed tomography scan images in axial section of the patient showing prechemotherapy disease extent (a) and complete metabolic response after completing chemotherapy (b)
See this image and copyright information in PMC

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