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. 2020 Feb;34(2):e13782.
doi: 10.1111/ctr.13782. Epub 2020 Jan 29.

Development of an objective, standardized tool for surgical assessment of deceased donor kidneys: The Cambridge Kidney Assessment Tool

John O O Ayorinde  1 , Mazin Hamed  1 , Mingzheng Aaron Goh  1 , Dominic M Summers  1 , Anna Dare  1 , Yining Chen  2 , Kourosh Saeb-Parsy  1
Affiliations

Development of an objective, standardized tool for surgical assessment of deceased donor kidneys: The Cambridge Kidney Assessment Tool

John O O Ayorinde et al. Clin Transplant. 2020 Feb.

Abstract

Quality assessment in kidney transplantation involves inspection to identify negative markers of organ quality. However, there is a paucity of evidence guiding surgical appraisal, and currently there is no evidence to differentiate important features from those that can be safely ignored. We propose a method to standardize surgical assessment and derived a simple rule to rapidly identify kidneys suitable for transplantation. Donor and recipient data were recorded alongside clinical outcomes in a prospectively maintained database. We developed a proforma (Cambridge Kidney Assessment Tool, CKAT) and used it to assess deceased donor kidney transplants. Factors predictive of utilization were identified by multivariate and univariate logistic regression analysis of CKAT-assessment scores, and test performance was evaluated using standard 2 × 2 contingency tables. Ninety-seven kidneys were included at a single center (2013-2014), and 184 CKAT assessments were performed. A CKAT threshold of "Carrell + Perfusion >3" was highly specific (99%) and performed favorably to consultant opinion (specificity 95%). 96% of the kidneys implanted in accordance with the rule survived to 1 year (mean eGFR 45.3 mL/min/1.73 m2 ). To our knowledge, this is the first attempt to objectively define macroscopic features that are relevant to kidney utilization. Common language could support training in organ assessment and ultimately help address unnecessary discard of donor kidneys.

Keywords: deceased donor transplant; kidney; macroscopic assessment; proforma; surgical assessment; utilization.

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References

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