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Multicenter Study
. 2020 Jan 20;22(1):13.
doi: 10.1186/s13075-020-2098-1.

Reduced progression of bone erosion in cytomegalovirus seropositive rheumatoid arthritis patients

B Rauwel  1 , Y Degboé  1   2   3 , D Nigon  1   3   4 , J-F Boyer  1   2 , F Abravanel  1   5 , J Izopet  1   5 , B Combe  6 , A Ruyssen-Witrand  1   3   4 , A Constantin  1   2   3 , A Cantagrel  1   2   3 , J-L Davignon  7   8
Affiliations
Multicenter Study

Reduced progression of bone erosion in cytomegalovirus seropositive rheumatoid arthritis patients

B Rauwel et al. Arthritis Res Ther. .

Abstract

Background: Human cytomegalovirus (HCMV) seropositivity has been associated with higher inflammation during rheumatoid arthritis (RA). However, no data are available on the impact of HCMV seropositivity on bone erosion progression during RA.

Methods: We selected 487 individuals of ESPOIR cohort who fulfilled the 2010 ACR/EULAR criteria for RA. HCMV serology for these patients was determined using Architect CMV IgG assay. Baseline and 1-year central X-ray reading using modified Total Sharp Score (mTSS), Erosion Sharp Score, and joint space narrowing Sharp score were used to quantify structural damage progression. We performed univariate and multivariate analyses to investigate the association between HCMV status and bone erosion progression.

Results: We analyzed 273 HCMV seropositive (HCMV+) and 214 HCMV seronegative (HCMV-) RA patients. At inclusion, HCMV+ patients were less frequently ACPA+ (49.8% versus 58.9%, p < 0.0465) and had a higher DAS28-ESR (5.55 ± 1.24 versus 5.20 ± 1.14, p < 0.0013) in comparison with HCMV-. At 1 year, bone erosion progression (delta erosion Sharp score > 1 point) was lower in HCMV+ patients (16.1% versus 25.2%, p = 0.0128) in comparison with HCMV-. HCMV+ status remained independently associated with lower bone erosion progression in multivariate analysis.

Conclusions: Our findings suggest that, independently of other confounding factors, HCMV seropositivity is associated with a lower progression of bone erosion during RA.

Keywords: Bone erosion; ESPOIR cohort; Human cytomegalovirus; Inflammation; Rheumatoid arthritis.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
HCMV seropositivity is associated with a lower bone erosion progression during rheumatoid arthritis, study of ESPOIR cohort. a Delta erosion Sharp score evolution (0–1 year) is represented for 214 HCMV− and 273 HCMV+ RA patients from the ESPOIR cohort. (n = 487, *p < 0.05, error bars as SD). b, c Cumulative probability plots of the progression of ESS (erosion Sharp score) and NSS (joint space narrowing Sharp score) within 1 year according to HCMV status
See this image and copyright information in PMC

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