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Review
. 2020 Apr 1:304:101-108.
doi: 10.1016/j.ijcard.2020.01.003. Epub 2020 Jan 9.

Heart failure with preserved ejection fraction: Similarities and differences between women and men

Carl J Pepine  1 , C Noel Bairey Merz  2 , Stephanie El Hajj  3 , Keith C Ferdinand  4 , Michele A Hamilton  2 , Kathryn J Lindley  5 , Michael D Nelson  6 , Odayme Quesada  2 , Nanette K Wenger  7 , Jerome L Fleg  8 ; American College of Cardiology Committee on Cardiovascular Disease in Women
Affiliations
Review

Heart failure with preserved ejection fraction: Similarities and differences between women and men

Carl J Pepine et al. Int J Cardiol. .

Abstract

The syndrome of heart failure (HF) with preserved ejection fraction (HFpEF) is now recognized to account for up to half of HF cases and is the dominant form of HF in older adults, especially women. Multiple factors conspire in this predilection of HFpEF for older women. This review will discuss the epidemiology, pathophysiology, prognosis, and treatment of HFpEF with emphasis on the similarities and differences in cardiovascular aging changes, and the differential impact of comorbidities in women versus men. Responses to pharmacologic and lifestyle interventions are also reviewed. We conclude by suggesting future directions for both prevention and treatment of this common and highly morbid cardiovascular disorder.

Keywords: Heart failure with preserved ejection fraction; Older women; Sex differences.

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