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Meta-Analysis
. 2020 Jan 20;10(1):728.
doi: 10.1038/s41598-020-57582-x.

The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis

Hadis Najafimehr  1 , Nastaran Hajizadeh  2 , Ehsan Nazemalhosseini-Mojarad  1 , Mohamad Amin Pourhoseingholi  3 , Meghdad Abdollahpour-Alitappeh  4 , Sara Ashtari  2 , Mohammad Reza Zali  1
Affiliations
Meta-Analysis

The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis

Hadis Najafimehr et al. Sci Rep. .

Abstract

The prognostic role of Human leukocyte antigen class I (HLA- I) in gastrointestinal cancers has been remained controversial. We performed a meta-analysis to determine the role of classical HLA-I in predicting survival of patients. In addition, the relationship between HLA- I and some clinicopathological factors was evaluated. Published studies investigated HLA-I expression effect on gastrointestinal cancers were evaluated to determine association between HLA- I and overall survival (OS) and recurrence-free survival (RFS) in patients. The used effect sizes were hazard ratio (HR) and Odds ratio (OR) with 95% confidence interval (CI). A total of ten studies included 1307 patients were analyzed. The pooled results revealed that HLA- I overexpression was positively related to OS (HR: 0.72; 95% CI: 0.53-0.96) and demonstrated little association for RFS (HR: 0.70; 95% CI: 0.46-1.08). HLA-I overexpression is negative associated with poorer differentiation of tumor (OR: 0.53; 95% CI (0.43-0.81) and also higher stages of cancer (OR: 0.29; 95% CI (0.13-0.64). HLA- I overexpression was related to a better prognosis on OS and probably had little impact on RFS.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flowchart of study selection process.
Figure 2
Figure 2
Forrest plot of pooled hazard ratio on the association between HLA- I overexpression and OS (a) and RFS (b) in gastrointestinal cancers.
Figure 3
Figure 3
Forrest plot of pooled odds ratio on the association between HLA- I overexpression and tumor differentiation (a) and stage (b).
See this image and copyright information in PMC

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