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. 1988 Sep;32(9):1336-40.
doi: 10.1128/AAC.32.9.1336.

In vitro activity of DR-3355, an optically active ofloxacin

T Une  1 , T Fujimoto, K Sato, Y Osada
Affiliations

In vitro activity of DR-3355, an optically active ofloxacin

T Une et al. Antimicrob Agents Chemother. 1988 Sep.

Abstract

DR-3355, the S-(-)-isomer of ofloxacin, was generally twice as potent as ofloxacin against a variety of gram-positive and gram-negative pathogens, and its action was bactericidal. The compound was characterized by having the highest level of activity against staphylococci, Bacteroides fragilis, and Peptococcus spp. of the fluorinated quinolones tested, including ofloxacin, ciprofloxacin, fleroxacin, and NY-198. The activity of DR-3355 was not affected by different media, inoculum size, or human serum, but decreased under acidic conditions at pH 5.0 or in human urine.

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References

    1. Antimicrob Agents Chemother. 1980 Feb;17(2):103-8 - PubMed
    1. Antimicrob Agents Chemother. 1980 Nov;18(5):699-708 - PubMed
    1. Antimicrob Agents Chemother. 1982 Oct;22(4):548-53 - PubMed
    1. Antimicrob Agents Chemother. 1983 Jan;23(1):142-50 - PubMed
    1. Antimicrob Agents Chemother. 1983 Apr;23(4):559-64 - PubMed

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