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Observational Study
. 2020 Jun;41(6):1513-1519.
doi: 10.1007/s10072-019-04230-6. Epub 2020 Jan 20.

Multiple sclerosis and neuromyelitis optica spectrum disorders in Argentina: comparing baseline data from the Argentinean MS Registry (RelevarEM)

Juan Ignacio Rojas  1   2 , Marina Alonso Serena  3 , Orlando Garcea  4 , Liliana Patrucco  5 , Adriana Carrá  6   7 , Jorge Correale  8 , Carlos Vrech  9 , Agustín Pappolla  5 , Jimena Miguez  5 , María L Doldan  5   10 , Facundo Silveira  5 , Ricardo Alonso  4   11 , Leila Cohen  4 , Cecilia Pita  4 , Berenice A Silva  4 , Marcela Fiol  8 , María I Gaitán  8 , Mariano Marrodan  8 , Laura Negrotto  8 , María C Ysrraelit  8 , Norma Deri  12 , Geraldine Luetic  13 , Alejandro Caride  14 , Edgar Carnero Contentti  14 , Pablo A Lopez  14 , Juan Pablo Pettinicchi  14 , Celeste Curbelo  6   15 , Alejandra D Martinez  6 , Judith D Steinberg  6 , María E Balbuena  16 , Verónica Tkachuk  16 , Marcos Burgos  17 , Eduardo Knorre  18 , Felisa Leguizamon  18 , Raúl Piedrabuena  19   20 , Susana Del V Liwacki  19   21 , Andrés G Barboza  22 , Pedro Nofal  23 , Gabriel Volman  24 , Amelia Alvez Pinheiro  25 , Javier Hryb  26 , Dario Tavolini  27 , Patricio A Blaya  28 , Emanuel Silva  29 , Jorge Blanche  30 , Santiago Tizio  31 , Fernando Caceres  32 , María Laura Saladino  32 , Gisela Zanga  33 , María E Fracaro  34 , Gustavo Sgrilli  35 , Fátima Pagani Cassara  36 , Guido Vazquez  7 , Vladimiro Sinay  36 , María Laura Menichini  37 , Luciana Lazaro  11 , Lorena M Cabrera  38   39 , Santiago Bestoso  40 , Pablo Divi  41 , Miguel Jacobo  41 , Eduardo Kohler  42 , Matías Kohler  42 , Diego Giunta  3 , Carolina Mainella  43 , Ruben Manzi  44 , Marcela Parada Marcilla  45 , Juan Pablo Viglione  46 , Ivan Martos  47 , Edgardo Reich  48 , Gustavo Jose  49 , Edgardo Cristiano  5   10 , Nora Fernández Liguori  11   50 ; on behalf RelevarEM investigators
Affiliations
Observational Study

Multiple sclerosis and neuromyelitis optica spectrum disorders in Argentina: comparing baseline data from the Argentinean MS Registry (RelevarEM)

Juan Ignacio Rojas et al. Neurol Sci. 2020 Jun.

Abstract

The objective of this study was to describe and compare the baseline epidemiological data of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) patients included in RelevarEM (Clinical Trials registry number NCT03375177).

Methods: RelevarEM is a longitudinal, strictly observational MS and NMOSD registry in Argentina. Epidemiological and comorbidity data from MS and NMOSD patients were described and compared. For comorbidities, the Charlson comorbidity index (CCI) was used to calculate the burden at entry. CCI was stratified in 0 and ≥ 1 and described for the entire cohort.

Results: A total of 1588 and 75 MS and NMOSD patients (respectively) were included. For MS patients, the mean age was 42 ± 7 years, female sex 65.3%, mean EDSS 2, and mean disease duration 8 ± 6 years. In NMOSD, the mean age was 40 ± 7 years, female sex 78.7%, mean disease duration 5 ± 3.5 years, and mean EDSS 2.5. The most frequent MS phenotype was RRMS in 82.4%. In MS, the CCI was 0 in 85.8.2% while ≥ 1 was in 14.2% of patients. Regarding phenotype stratification, CCI ≥ 1 was 3.9% in CIS, 13.5% in RRMS, 28.7% in SPMS, and 17.4% in PPMS (p < 0.001 between groups). In NMOSD, the CCI was 0 in 64% while ≥ 1 was in 36%. The MS/NMOSD ratio found was 21/1.

Conclusions: This is the first analysis of the longitudinal Argentinean registry of MS and NMOSD describing and comparing conditions that contributes to provide reliable real-world data in the country.

Keywords: Epidemiology; Multiple sclerosis; Neuromyelitis optica spectrum disorder; Registry; RelevarEM.

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