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Review
. 2020 Jan 21;9(2):e013754.
doi: 10.1161/JAHA.119.013754. Epub 2020 Jan 21.

Reverse Cardio-Oncology: Cancer Development in Patients With Cardiovascular Disease

Joseph Pierre Aboumsallem  1 , Javid Moslehi  2   3 , Rudolf A de Boer  1
Affiliations
Review

Reverse Cardio-Oncology: Cancer Development in Patients With Cardiovascular Disease

Joseph Pierre Aboumsallem et al. J Am Heart Assoc. .
No abstract available

Keywords: biomarker; cancer; cardiokines; cardiovascular disease; cardio‐oncology; inflammation; reverse cardio‐oncology; risk factor; somatic mutations.

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Figures

Figure 1
Figure 1
Graphic illustration showing somatic mutations in hematopoietic stem cells as a common path for cancer and cardiovascular disease.
Figure 2
Figure 2
Theoretical depiction of the mechanisms by which hypoxia contributes to cancer growth and angiogenesis. HIF‐1 indicates hypoxia‐inducible factor 1; VEGF, vascular endothelial growth factor.
Figure 3
Figure 3
Theoretical depiction of cardiac secretome and its effect on tumor development, mobility, and metastasis.
Figure 4
Figure 4
Illustration of the reverse cardio‐oncology clinical end points. CHIP indicates clonal hematopoiesis of indeterminate potential; CVD, cardiovascular disease.
See this image and copyright information in PMC

References

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    1. American Cancer Society . Cancer Treatment & Survivorship Facts & Figures 2019–2021. Atlanta, GA: American Cancer Society; 2019.
    1. American Cancer Society . Cancer Facts & Figures 2019. Atlanta, GA: American Cancer Society; 2019.
    1. Hasin T, Iakobishvili Z, Weisz G. Associated risk of malignancy in patients with cardiovascular disease: evidence and possible mechanism. Am J Med. 2017;130:780–785. - PubMed

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