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Review
. 2020 Apr;31(4):975-984.
doi: 10.1111/jce.14361. Epub 2020 Jan 29.

Atrial fibrillation in Brugada syndrome: Current perspectives

Konstantinos Vlachos  1 , Giuseppe Mascia  2 , Claire A Martin  1   3 , George Bazoukis  4 , Antonio Frontera  1 , Ghassen Cheniti  1 , Konstantinos P Letsas  4 , Micheal Efremidis  4 , Stamatis Georgopoulos  4 , Charis Gkalapis  5   6 , Josselin Duchateau  1 , Thomas Parmbrun  1 , Nicholas Derval  1 , Mélèze Hocini  1 , Michel Haissaguerre  1 , Pierre Jais  1 , Frédéric Sacher  1
Affiliations
Review

Atrial fibrillation in Brugada syndrome: Current perspectives

Konstantinos Vlachos et al. J Cardiovasc Electrophysiol. 2020 Apr.

Abstract

The incidence of atrial fibrillation (AF) in Brugada syndrome (BrS) has been reported at between 9% and 53% by different series, but the true prevalence is unknown. However, AF may be the presenting feature in some patients. The underlying mechanisms for AF may be a combination of multiple factors, genetic or acquired, that may impact upon autonomic function, atrial structure, and conduction velocities or other unknown factors. The presence of AF has been associated with a more malignant course, with a greater incidence of syncope and ventricular arrhythmias, thus acting as marker of more advanced disease. Regarding the management of patients with AF, antiarrhythmic drugs effective in preventing malignant arrhythmias in BrS such as quinidine or invasive treatment with pulmonary vein isolation (PVI) may be useful in AF treatment. In this review, we aim to present the current perspectives regarding the genetics, pathophysiology, management, and prognosis of AF in patients with BrS.

Keywords: Brugada syndrome; arrhythmia mechanism; atrial fibrillation; genetics.

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References

REFERENCES

    1. Sieira J, Brugada P. The definition of the Brugada syndrome. Eur Heart J. 2017;38:3029-3034.
    1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol. 1992;20:1391-1396.
    1. Eckardt L, Kirchhof P, Loh P, et al. Brugada syndrome and supraventricular tachyarrhythmias: a novel association? J Cardiovasc Electrophysiol. 2001;12:680-685.
    1. Itoh H, Shimizu M, Ino H, et al. Arrhythmias in patients with Brugada-type electrocardiographic findings. Jpn Circ J. 2001;65:483-486.
    1. Morita H, Kusano-Fukushima K, Nagase S, et al. Atrial fibrillation and atrial vulnerability in patients with Brugada syndrome. J Am Coll Cardiol. 2002;40:1437-1444.

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