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doi: 10.1016/j.cub.2019.11.060.
Cell Biology: Tight Junctions as Biomolecular Condensates
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- PMID: 31962084
- DOI: 10.1016/j.cub.2019.11.060
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Cell Biology: Tight Junctions as Biomolecular Condensates
Curr Biol.
.
Free article
Abstract
Two recent studies report that ZO proteins, the main scaffolding proteins of tight junctions, undergo liquid phase separation. This new concept provides understanding at the mechanistic level of how tight junctions are formed and how they participate in mechanochemical signaling in early development.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Comment on
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Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions.Cell. 2019 Oct 31;179(4):923-936.e11. doi: 10.1016/j.cell.2019.10.011. Cell. 2019. PMID: 31675499
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Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow.Cell. 2019 Oct 31;179(4):937-952.e18. doi: 10.1016/j.cell.2019.10.006. Cell. 2019. PMID: 31675500
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