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Comment
. 2020 Jan 20;30(2):R89-R91.
doi: 10.1016/j.cub.2019.11.087.

Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface

Wei Peng  1 , Jenna L Jewell  2
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Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface

Wei Peng et al. Curr Biol. .
Free article

Abstract

Amino acid signaling through the Rag GTPases promotes mTORC1 lysosomal localization and subsequent activation. Two new cryo-EM structures examine the architecture of the Rag GTPase heterodimers complexed with mTORC1.

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