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. 2020 Jan 16;10(1):47.
doi: 10.3390/diagnostics10010047.

HLA Allele and Haplotype Frequencies in Three Urban Mexican Populations: Genetic Diversity for the Approach of Genomic Medicine

Alma D Del Angel-Pablo  1   2 , Ana Itzel Juárez-Martín  3 , Gloria Pérez-Rubio  1 , Enrique Ambrocio-Ortiz  1 , Luis A López-Flores  1 , Angel E Camarena  1 , Ramcés Falfán-Valencia  1
Affiliations

HLA Allele and Haplotype Frequencies in Three Urban Mexican Populations: Genetic Diversity for the Approach of Genomic Medicine

Alma D Del Angel-Pablo et al. Diagnostics (Basel). .

Abstract

Genetic variability defends us against pathogen-driven antigens; human leucocyte antigens (HLA) is the immunological system in charge of this work. The Mexican mestizo population arises mainly from the mixture of three founder populations; Amerindian, Spaniards, and a smaller proportion of the African population. We describe allele and haplotype frequencies of HLA class I (-A and -B) and class II (-DRB1 and -DQB1), which were analyzed by PCR-SSP in Mexican mestizo from three urban populations of Mexico: Chihuahua-Chihuahua City (n = 88), Mexico City-Tlalpan (n = 330), and Veracruz-Xalapa (n = 84). The variability of the allele HLA class I and class II among the three regions of Mexico are in four alleles: HLA-A*24:02 (36.39%), -B*35:01 (16.04%), -DRB1*04:07 (17.33%), and -DQB1*03:02 (31.47%), these alleles have been previously described in some indigenous populations. We identified 5 haplotypes with a frequency >1%: HLA-A*02:01-B*35:01-DRB1*08:02-DQB1*04:02, A*68:01-B*39:01-DRB1*08:02-DQB1*04:02, A*02:01-B*35:01-DRB1*04:07-DQB1*03:02, A*68:01-B*39:01-DRB1*04:07-DQB1*03:02, and A*01:01-B*08:01-DRB1*03:01-DQB1*02:01. Also, the haplotype A*02:01-B*35:01-DRB1*08:02-DQB1*04:02 was identified in Tlalpan and Xalapa regions. Haplotype A*01:01-B*08:01-DRB1*03:01-DQB1*02:01 was found only in Tlalpan and Chihuahua. In the Xalapa region, the most frequent haplotype was A*24:02-B*35:01-DRB1*04:07-DQB1*03:02. These alleles and haplotypes have been described in Amerindian populations. Our data are consistent with previous studies and contribute to the analysis of the variability in the Mexican population.

Keywords: Chihuahua; HLA; Tlalpan; Xalapa; biobank; haplotype; population genetics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Geographical representation of Mexico showing the location of included populations. Chihuahua City (yellow point), located at the State of Chihuahua; Tlalpan (blue point), located at Mexico City, and Xalapa (red point), located at the State of Veracruz.
Figure 2
Figure 2
Venn diagram for the regions: Tlalpan, Chihuahua, and Xalapa. (a) HLA-A alleles shared in the three regions; (b) HLA-B alleles shared in the three regions, (c) HLA-DRB1 alleles shared in the three regions, (d) HLA-DQB1 alleles shared in the three regions.
See this image and copyright information in PMC

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