Comment
doi: 10.1016/j.tips.2020.01.004.
Epub 2020 Jan 18.
Opioid-Induced Adaptations of cAMP Dynamics in the Nucleus Accumbens
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- PMID: 31964511
- DOI: 10.1016/j.tips.2020.01.004
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Comment
Opioid-Induced Adaptations of cAMP Dynamics in the Nucleus Accumbens
Trends Pharmacol Sci.
2020 Apr.
Abstract
To investigate how opioid exposure alters dopamine (DA) responses in medium spiny neurons (MSNs), Muntean et al. used a novel cAMP sensor to track cAMP dynamics and report a coordinated effort of adaptations in D1- and D2-MSNs to integrate DA inputs and shift signaling strengths in various states of opioid dependence.
Keywords: GPCR; dopamine; opioid; striatum; striosome.
Copyright © 2020 Elsevier Ltd. All rights reserved.
Comment on
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Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits.Cell Rep. 2018 Jan 2;22(1):255-268. doi: 10.1016/j.celrep.2017.12.022. Cell Rep. 2018. PMID: 29298426 Free PMC article.
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Allostatic Changes in the cAMP System Drive Opioid-Induced Adaptation in Striatal Dopamine Signaling.Cell Rep. 2019 Oct 22;29(4):946-960.e2. doi: 10.1016/j.celrep.2019.09.034. Cell Rep. 2019. PMID: 31644915 Free PMC article.
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