GORK Channel: A Master Switch of Plant Metabolism?

Abstract

Potassium regulates a plethora of metabolic and developmental response in plants, and upon exposure to biotic and abiotic stresses a substantial K⁺ loss occurs from plant cells. The outward-rectifying potassium efflux GORK channels are central to this stress-induced K⁺ loss from the cytosol. In the mammalian systems, signaling molecules such as gamma-aminobutyric acid, G-proteins, ATP, inositol, and protein phosphatases were shown to operate as ligands controlling many K⁺ efflux channels. Here we present the evidence that the same molecules may also regulate GORK channels in plants. This mechanism enables operation of the GORK channels as a master switch of the cell metabolism, thus adjusting intracellular K⁺ homeostasis to altered environmental conditions, to maximize plant adaptive potential.

Keywords: ATP; G-protein; GABA; cyclic nucleotide; molecular evolution; potassium efflux channel.