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Comment
. 2020 Jan 28;117(4):1847-1848.
doi: 10.1073/pnas.1917278117. Epub 2020 Jan 21.

Reply to Soulillou et al.: Difficulties in extrapolating from animal models exemplify unusual human atherosclerosis susceptibility and mechanisms via CMAH loss

Kunio Kawanishi  1   2 , Chirag Dhar  1   2 , Ajit Varki  3   2   4   5 , Philip L S M Gordts  3   2   4
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Comment

Reply to Soulillou et al.: Difficulties in extrapolating from animal models exemplify unusual human atherosclerosis susceptibility and mechanisms via CMAH loss

Kunio Kawanishi et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

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References

    1. Soulillou J.-P., Cozzi E., Galli C., Bach J.-M., Can we extrapolate from a Cmah−/−Ldlr−/− mouse model a susceptibility for atherosclerosis in humans? Proc. Natl. Acad. Sci. U.S.A. 117, 1845–1846 (2020). - PMC - PubMed
    1. Kawanishi K., et al. , Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms. Proc. Natl. Acad. Sci. U.S.A. 116, 16036–16045 (2019). - PMC - PubMed
    1. Okerblom J., Varki A., Biochemical, cellular, physiological, and pathological consequences of human loss of N-glycolylneuraminic acid. ChemBioChem 18, 1155–1171 (2017). - PubMed
    1. Dhar C., Sasmal A., Varki A., From “serum sickness” to “xenosialitis”: Past, present, and future significance of the non-human sialic acid Neu5Gc. Front. Immunol. 10, 807 (2019). - PMC - PubMed
    1. Pham T., et al. , Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium. Blood 114, 5225–5235 (2009). - PMC - PubMed

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