Can we extrapolate from a Cmah -/- Ldlr -/- mouse model a susceptibility for atherosclerosis in humans?
- PMID: 31964838
- PMCID: PMC6995011
- DOI: 10.1073/pnas.1915658117
Can we extrapolate from a Cmah -/- Ldlr -/- mouse model a susceptibility for atherosclerosis in humans?
Conflict of interest statement
The authors declare no competing interest.
Comment in
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Reply to Soulillou et al.: Difficulties in extrapolating from animal models exemplify unusual human atherosclerosis susceptibility and mechanisms via CMAH loss.Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):1847-1848. doi: 10.1073/pnas.1917278117. Epub 2020 Jan 21. Proc Natl Acad Sci U S A. 2020. PMID: 31964837 Free PMC article. No abstract available.
Comment on
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Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms.Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16036-16045. doi: 10.1073/pnas.1902902116. Epub 2019 Jul 22. Proc Natl Acad Sci U S A. 2019. PMID: 31332008 Free PMC article.
References
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- Le Berre L., et al. , Elicited and pre-existing anti-Neu5Gc antibodies differentially affect human endothelial cells transcriptome. Xenotransplantation 26, e12535 (2019). - PubMed
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