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Randomized Controlled Trial
. 2020 Apr;35(4):1120-1126.
doi: 10.1007/s11606-020-05658-9. Epub 2020 Jan 21.

Cost-effectiveness of Practice Team-Supported Exposure Training for Panic Disorder and Agoraphobia in Primary Care: a Cluster-Randomized Trial

Christian Brettschneider  1 , Jochen Gensichen  2   3 , Thomas S Hiller  3 , Jörg Breitbart  3 , Ulrike Schumacher  4 , Karoline Lukaschek  2 , Tobias Teismann  5 , Jürgen Margraf  5 , Hans-Helmut König  6
Affiliations
Free PMC article
Randomized Controlled Trial

Cost-effectiveness of Practice Team-Supported Exposure Training for Panic Disorder and Agoraphobia in Primary Care: a Cluster-Randomized Trial

Christian Brettschneider et al. J Gen Intern Med. 2020 Apr.
Free PMC article

Abstract

Background: Primary care is the main treatment setting for panic disorder and should be supplemented by collaborative care programs. However, shortage of mental health professionals prevents collaborative care programs from being effectively implemented. The PARADISE study showed the efficacy of a self-managed, cognitive-behavioural therapy (CBT)-oriented exposure training for patients with panic disorder with or without agoraphobia in primary care delivered by the family practice team.

Objective: To assess the cost-effectiveness of the PARADISE intervention.

Design: Cost-effectiveness analysis from the societal perspective based on data from a cluster-randomized controlled trial over a time horizon of 12 months.

Participants: Four hundred nineteen adult panic disorder patients with or without agoraphobia.

Interventions: A self-managed, CBT-oriented exposure training for patients with panic disorder with or without agoraphobia in primary care delivered by the primary care practice team in comparison to routine care.

Main measures: Total costs from the societal perspective. Direct costs and disease-specific costs. Quality-adjusted life years based on the EQ-5D-3L. Incremental cost-effectiveness ratios and cost-effectiveness acceptability curves.

Key results: Patients in the intervention group caused lower costs (mean, €1017; 95% confidence interval [-€3306; €1272]; p = 0.38) and gained on average more QALY (mean, 0.034 QALY (95% confidence interval [0.005; 0.062]; p = 0.02). Therefore, the intervention dominated the control treatment. The probability of cost-effectiveness of the intervention at a willingness-to-pay margin of €50,000 per QALY was 96%. Results from supplementary analyses considering direct or disease-specific costs instead of total costs showed comparable results.

Conclusion: The PARADISE intervention is cost effective. This conclusion is valid for total costs, generic health care (direct) costs, disease-specific health care costs.

Trial registration: German Clinical Trials Register: DRKS00004386 Current Controlled Trials: ISRCTN64669297.

Keywords: cost-effectiveness; mental health; primary care; self-management.

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