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Review
. 2020 Jul;154(1):11-24.
doi: 10.1111/jnc.14968. Epub 2020 Feb 3.

The biochemical basis of interactions between Glucocerebrosidase and alpha-synuclein in GBA1 mutation carriers

Marco Toffoli  1 , Laura Smith  1 , Anthony H V Schapira  1
Affiliations
Free article
Review

The biochemical basis of interactions between Glucocerebrosidase and alpha-synuclein in GBA1 mutation carriers

Marco Toffoli et al. J Neurochem. 2020 Jul.
Free article

Abstract

The discovery of genes involved in familial as well as sporadic forms of Parkinson disease (PD) constitutes an important milestone in understanding this disorder's pathophysiology and potential treatment. Among these genes, GBA1 is one of the most common and well-studied, but it is still unclear how mutations in GBA1 translate into an increased risk for developing PD. In this review, we provide an overview of the biochemical and structural relationship between GBA1 and PD to help understand the recent advances in the development of PD therapies intended to target this pathway.

Keywords: GBA1; Gaucher disease; Parkinson disease; alpha-synuclein.

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References

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