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. 2020 Mar;9(6):2235-2242.
doi: 10.1002/cam4.2864. Epub 2020 Jan 21.

Race, tumor location, and disease progression among low-risk prostate cancer patients

Justin G Mygatt  1 , Jennifer Cullen  2   3 , Samantha A Streicher  2   3 , Huai-Ching Kuo  2   3 , Yongmei Chen  2   3 , Denise Young  2   3 , William Gesztes  4 , Grant Williams  4 , Galen Conti  2   3 , Christopher Porter  2 , Sean P Stroup  2 , Kevin R Rice  1 , Inger L Rosner  1   2 , Allen Burke  4 , Isabell Sesterhenn  4
Affiliations

Race, tumor location, and disease progression among low-risk prostate cancer patients

Justin G Mygatt et al. Cancer Med. 2020 Mar.

Abstract

Background: The relationship between race, prostate tumor location, and BCR-free survival is inconclusive. This study examined the independent and joint roles of patient race and tumor location on biochemical recurrence-free (BCR) survival.

Methods: A retrospective cohort study was conducted among men with newly diagnosed, biopsy-confirmed, NCCN-defined low risk CaP who underwent radical prostatectomy (RP) at the Walter Reed National Military Medical Center from 1996 to 2008. BCR-free survival was modeled using Kaplan-Meier estimation curves and multivariable Cox proportional hazards (PH) analyses.

Results: There were 539 eligible patients with low-risk CaP (25% African American, AA; 75% Caucasian American, CA). Median age at CaP diagnosis and post-RP follow-up time was 59.2 and 8.1 years, respectively. Kaplan-Meier analyses showed no significant association between race (P = .52) or predominant tumor location (P = .98) on BCR-free survival. In Cox PH multivariable analysis, neither race (HR = 1.18; 95% CI = 0.68-2.02; P = .56) nor predominant tumor location (HR = 1.13; 95% CI = 0.59-2.15; P = .71) was an independent predictor of BCR-free survival.

Conclusions: Neither race nor predominant tumor location was associated with adverse oncologic outcome.

Keywords: general surgery; prostatic neoplasms; race factors; risk.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
A‐C, Transverse section of the prostate showing anteriora, posteriorb, and peri‐urethral regions. All categorizations were assigned as part of a centralized pathologic review (I.S.). Percent of tumors located in the six regions of the prostate for overall study cohort (N=539)c,d (A), Caucasian American men (N=402)c,d (B), African American men (N=137)c,d (C). aRegions in blue comprised the anterior portion of the prostate. bRegions in orange plus diffuse tumors comprised the non‐anterior portion of the prostate. c7.6% of prostate tumors in the entire cohort, 6.7% of prostate tumors in Caucasian American men, and 10.7% of prostate tumors in African American men were diffuse prostate tumors. d3.9% of prostate tumors in the entire cohort, 4.1% of prostate tumors in Caucasian American men, and 3.6% of prostate tumors in African American men were either right or left sided anterior lateral or posterior lateral prostate tumors, but with 1% to 50% involvement with the other side
Figure 2
Figure 2
A, B, Biochemical recurrence‐free survival for men eligible for active surveillance over more than 15 y after radical prostatectomy. A, Stratified by race. B, Stratified by predominant tumor location
See this image and copyright information in PMC

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