Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Oct 1;10(10):10431-10440.
eCollection 2017.

Expression of beta adrenergic receptor in oral squamous cell carcinoma and its significance to the prognosis

Hao Dong  1   2 , Xian-Xiang Liao  1 , Hua-Ming Mai  1 , Nuo Zhou  1 , Dai-You Wang  1 , Jian-Bo Peng  1 , Liang-Hui Yang  1
Affiliations

Expression of beta adrenergic receptor in oral squamous cell carcinoma and its significance to the prognosis

Hao Dong et al. Int J Clin Exp Pathol. .

Abstract

The aim of this study was to detect the expression of β-AR (Beta Adregenic Receptor) in Oral squamous cell carcinoma (OSCC), para-cancerous and normal oral mucosa and to investigate the relationship between the expression intensity and the characteristics and prognosis of oral cancer. 100 cases of OSCC were collected; 20 cases of paraneoplastic tissues and 10 cases of normal oral mucosa were taken as control. The expression of β-AR was detected by immunohistochemical method and the average optical density determination using Image J software. Finally, the difference of β-AR expression and the correlation with the clinicopathological factors were analyzed statistically. The expression of β-AR in OSCC was higher than that in paracarcinoma and normal mucosa (P<0.01). The expression intensity of β1, β2-AR in preoperative lymph node metastasis group was higher than that in patients without lymph node metastasis (P<0.01). The expression intensity of β3-AR was not related to pathological grade and tumor size (P>0.05). β1 and β2-AR in early stage of OSCC were higher than those in early stage (P<0.05). Lymph node metastasis, recurrence, TNM clinical stage, and the expression intensity of β1-AR all had an effect on the cumulative survival rate. All the β1, 2, 3-AR were expressed in OSCC. β1 and β2-AR were involved in lymphatic metastasis and had influence on clinical staging. Metastasis, recurrence, TNM stage and expression of β1-AR had an effect on the cumulative survival rate of tumor. The expression of β3-AR in OSCC was not associated with the pathological grades and tumor growth.

Keywords: Oral squamous cell carcinoma; lymph node; metastasis; prognosis; β-adrenergic receptor.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Expressions of β-adrenergic receptor in normal oral mucosa tissues, OSCC tissues and the relevant para-carcinoma tissues (Immunohistochemical method, 400×). The expression of β1-AR, β2-AR and β3-AR in normal mucosa (Aa, Ba and Ca); in paracancerous tissues (Ab, Bb and Cb); in OSCC (Ac, Bc and Cc); the comparison of three groups of average optical density values, β1-AR, Ad; β2-AR, Bd; β3-AR, Cd.
Figure 2
Figure 2
β-AR expression and CS. Blue solid line indicates the β-AR low expression group; solid green line, the β-AR high expression group.
See this image and copyright information in PMC

References

    1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Intern J Cancer. 2010;127:2893–2917. - PubMed
    1. Al-Wadei HA, Plummer HK 3rd, Ullah MF, Unger B, Brody JR, Schuller HM. Social stress promotes and gamma-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancer. Cancer Prev Res (Phila) 2012;5:189–196. - PMC - PubMed
    1. Al-Wadei HA, Al-Wadei MH, Ullah MF, Schuller HM. Celecoxib and GABA cooperatively prevent the progression of pancreatic cancer in vitro andin xenograft models of stress-free and stress-exposed mice. PLoS One. 2012;7:e43376. - PMC - PubMed
    1. Moretti S, Massi D, Farini V, Baroni G, Parri M, Innocenti S, Cecchi R, Chiarugi P. Beta-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines. Lab Invest. 2013;93:279–290. - PubMed
    1. Wong HP, Ho JW, Koo MW, Yu L, Wu WK, Lam EK, Tai EK, Ko JK, Shin VY, Chu KM, Cho CH. Effects of adrenalinein human colon adenocarcinoma HT-29 cells. Life Sci. 2011;88:1108–1112. - PubMed

LinkOut - more resources