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. 2020 Feb;17(2):e1900631.
doi: 10.1002/cbdv.201900631. Epub 2020 Jan 22.

Synthesis of Taxol and Docetaxel by Using 10-Deacetyl-7-xylosyltaxanes

Baoyu Xue  1 , Junhong Zhao  1 , Yange Fan  1 , Shipeng Chen  1 , Wenfeng Li  1 , Jin Chen  1 , Zheng Li  1 , Hongxing Wang  1 , Hongjun Kong  1
Affiliations

Synthesis of Taxol and Docetaxel by Using 10-Deacetyl-7-xylosyltaxanes

Baoyu Xue et al. Chem Biodivers. 2020 Feb.

Abstract

A mixture of taxols was prepared from 10-deacetyl-7-xylosyltaxanes by three-step reactions: redox, acetylation, and deacetylation. The mixture was separated by column chromatography on silica gel to afford Taxol, Taxol B (Cephalomannine) and Taxol C. The mixture of Taxol B and Taxol C was converted to Docetaxel by Schwartz's reagent. The structures of Taxol and Docetaxel were characterized by HPLC, 1 H-NMR, 13 C-NMR and MS. This synthetic process has expanded the source of biomass for the chemical semi-synthesis of Taxol and Docetaxel, reduced the production costs, and increased the biomass resource of taxanes.

Keywords: Docetaxel; Taxol; synthesis; taxane compounds.

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