A LIGHTning Strike to the Metastatic Niche
- PMID: 31968238
- DOI: 10.1016/j.celrep.2020.01.027
A LIGHTning Strike to the Metastatic Niche
Abstract
Tumor-induced vascular alterations in distant organs have been linked to the spreading of cancer. In this issue of Cell Reports, He et al. (2019) show that targeting the cytokine LIGHT to the pulmonary vasculature prevents the establishment of lung metastasis in mice.
Copyright © 2020. Published by Elsevier Inc.
Comment on
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Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy.Cell Rep. 2020 Jan 21;30(3):714-724.e5. doi: 10.1016/j.celrep.2019.12.013. Cell Rep. 2020. PMID: 31968248
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