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Case Reports
. 2019 Dec 20;11(12):e6432.
doi: 10.7759/cureus.6432.

Inflammatory Myofibroblastic Tumor of the Lung: An Extremely Rare Condition in Adults

Ammar Al-Obaidi  1 , Charles Buess  1 , Job Mogire  1 , Pavan S Reddy  1
Affiliations
Case Reports

Inflammatory Myofibroblastic Tumor of the Lung: An Extremely Rare Condition in Adults

Ammar Al-Obaidi et al. Cureus. .

Abstract

Inflammatory myofibroblastic tumors (IMTs) of the lung were first reported in 1939. The most common site of predilection is the lungs of the pediatric population. They are extremely rare in adults, constituting less than 1% of adult lung tumors. They are mesenchymal neoplasms that may arise in the soft tissues of almost every organ. IMTs often arise from excessive inflammatory response, and as the name implies, they are composed of myofibroblastic spindle cells accompanied by an inflammatory infiltrate of plasma cells, lymphocytes, and eosinophils.

Keywords: inflammatory myofibroblastic tumor; inflammatory pseudotumor; lung tumors; pseudotumor.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. CT scan of the chest with contrast
1.3 cm opacity in the right upper lobe (A); 2.3 cm nodule in the right lower lobe and 1.4 cm nodule in the left lower lobe (B) Several additional pulmonary nodules are identified within the left lower lobe and lingula; no significant pleural effusion; no pneumothorax; scattered vascular calcifications
Figure 2
Figure 2. CT/PET scan
A hypermetabolic nodule in the right lower lobe CT/PET: positron emission tomography-computed tomography
Figure 3
Figure 3. The pathology specimen demonstrates the characteristic features, including spindle-shaped cells with a high nucleocytoplasmic ratio, pleomorphic hyperchromatic nuclei, brisk mitosis without atypia and intense inflammatory cell infiltrate, especially plasma cells
Morphology of IMT demonstrated (H&E stain A: 100X magnification and B: 400X magnification), (Immunohistochemical staining C: Kappa 400X magnification and D: Lambda 400X magnification) IMT: inflammatory myofibroblastic tumors; H&E: hematoxylin and eosin
See this image and copyright information in PMC

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