Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun;95(6):516-531.
doi: 10.1111/tan.13811. Epub 2020 Jan 31.

Common, intermediate and well-documented HLA alleles in world populations: CIWD version 3.0.0

Carolyn K Hurley  1 , Jane Kempenich  2 , Kim Wadsworth  2 , Jürgen Sauter  3 , Jan A Hofmann  3 , Daniel Schefzyk  3 , Alexander H Schmidt  3 , Pablo Galarza  4 , Maria B R Cardozo  4 , Malgorzata Dudkiewicz  5 , Lucie Houdova  6 , Pavel Jindra  7 , Betina S Sorensen  8 , Latha Jagannathan  9   10 , Ankit Mathur  10 , Tiina Linjama  11 , Tigran Torosian  12 , Rafi Freudenberger  13 , Anastasios Manolis  14 , John Mavrommatis  14 , Nezih Cereb  15 , Sigal Manor  16 , Nira Shriki  16 , Nicoletta Sacchi  17 , Reem Ameen  18 , Raewyn Fisher  19 , Heather Dunckley  20 , Irene Andersen  21 , Ahmed Alaskar  22 , Mohsen Alzahrani  22 , Ali Hajeer  22 , Dunia Jawdat  22 , Grazia Nicoloso  23 , Pawinee Kupatawintu  24 , Louise Cho  25 , Ashminder Kaur  25 , Mats Bengtsson  26 , Jason Dehn  2
Affiliations

Common, intermediate and well-documented HLA alleles in world populations: CIWD version 3.0.0

Carolyn K Hurley et al. HLA. 2020 Jun.

Abstract

A catalog of common, intermediate and well-documented (CIWD) HLA-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5, -DQB1 and -DPB1 alleles has been compiled from over 8 million individuals using data from 20 unrelated hematopoietic stem cell volunteer donor registries. Individuals are divided into seven geographic/ancestral/ethnic groups and data are summarized for each group and for the total population. P (two-field) and G group assignments are divided into one of four frequency categories: common (≥1 in 10 000), intermediate (≥1 in 100 000), well-documented (≥5 occurrences) or not-CIWD. Overall 26% of alleles in IPD-IMGT/HLA version 3.31.0 at P group resolution fall into the three CIWD categories. The two-field catalog includes 18% (n = 545) common, 17% (n = 513) intermediate, and 65% (n = 1997) well-documented alleles. Full-field allele frequency data are provided but are limited in value by the variations in resolution used by the registries. A recommended CIWD list is based on the most frequent category in the total or any of the seven geographic/ancestral/ethnic groups. Data are also provided so users can compile a catalog specific to the population groups that they serve. Comparisons are made to three previous CWD reports representing more limited population groups. This catalog, CIWD version 3.0.0, is a step closer to the collection of global HLA frequencies and to a clearer view of HLA diversity in the human population as a whole.

Keywords: HLA; alleles; ethnic groups; gene frequency.

PubMed Disclaimer

Conflict of interest statement

Hurley has been a histocompatibility advisor for the NMDP. Georgetown University has filed a patent application on which Hurley is an inventor of the HLA typing and Sanger‐based sequencing technology.

Figures

Figure 1
Figure 1
Distribution of HLA alleles into three frequency categories (common, intermediate, well‐documented) at P group (two‐field) resolution
Figure 2
Figure 2
Distribution of HLA alleles into three frequency categories at G group resolution
Figure 3
Figure 3
Distribution of nonexpressed HLA alleles into three frequency categories and 1‐4 occurrences at P group resolution
See this image and copyright information in PMC

Comment in

References

    1. Lee SJ, Klein J, Haagenson M, et al. High‐resolution donor‐recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007;110(13):4576‐4583. - PubMed
    1. Pidala J, Lee SJ, Ahn KW, et al. Nonpermissive HLA‐DPB1 mismatch increases mortality after myeloablative unrelated allogeneic hematopoietic cell transplantation. Blood. 2014;124(16):2596‐2606. - PMC - PubMed
    1. Williams RC, Opelz G, Weil EJ, McGarvey CJ, Chakkera HA. The risk of transplant failure with HLA mismatch in first adult kidney allografts 2: living donors, summary, guide. Transplant Direct. 2017;3(5):e152. - PMC - PubMed
    1. Williams RC, Opelz G, McGarvey CJ, Weil EJ, Chakkera HA. The risk of transplant failure with HLA mismatch in first adult kidney allografts from deceased donors. Transplantation. 2016;100(5):1094‐1102. - PMC - PubMed
    1. Kamoun M, McCullough KP, Maiers M, et al. HLA amino acid polymorphisms and kidney allograft survival. Transplantation. 2017;101(5):e170‐e177. - PMC - PubMed

Publication types

Substances