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Comment
. 2020 Jan 22;105(2):205-206.
doi: 10.1016/j.neuron.2020.01.001.

Aβ Puts the Alpha in Synuclein

Casey Cook  1 , Leonard Petrucelli  2
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Aβ Puts the Alpha in Synuclein

Casey Cook et al. Neuron. .
Free article

Abstract

Neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are characterized pathologically by aberrant protein accumulation, such as Aβ or α-synuclein deposition. In this issue of Neuron, Bassil et al. (2020) observed an exacerbation of α-syn pathology in the presence of Aβ plaques in vivo, with comorbid pathologies associated with greater neurodegeneration.

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