Greasing the Wheels of Regeneration

Rafi Kohen¹, Roman J Giger²

Affiliations

¹ Neuroscience Graduate Program, University of Michigan Medical School, 2045 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA.
² Neuroscience Graduate Program, University of Michigan Medical School, 2045 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA; Department of Cell & Developmental Biology, University of Michigan Medical School, 2045 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA; Department of Neurology, University of Michigan Medical School, 2045 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. Electronic address: rgiger@umich.edu.

PMID: 31972142
DOI: 10.1016/j.neuron.2019.11.032

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Greasing the Wheels of Regeneration

Rafi Kohen et al. Neuron. 2020.

Free article

. 2020 Jan 22;105(2):207-209.

doi: 10.1016/j.neuron.2019.11.032.

Authors

Rafi Kohen¹, Roman J Giger²

Affiliations

¹ Neuroscience Graduate Program, University of Michigan Medical School, 2045 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA.
² Neuroscience Graduate Program, University of Michigan Medical School, 2045 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA; Department of Cell & Developmental Biology, University of Michigan Medical School, 2045 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA; Department of Neurology, University of Michigan Medical School, 2045 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. Electronic address: rgiger@umich.edu.

PMID: 31972142
DOI: 10.1016/j.neuron.2019.11.032

Abstract

In this issue of Neuron, Yang et al. (2020) identify glycerolipid metabolism as a neuron-intrinsic mechanism that regulates axonal growth and regeneration. Shifting glycerolipid metabolism toward increased triglyceride synthesis blocks PNS neuron regeneration, whereas shifting it toward membrane phospholipid synthesis overcomes regeneration failure in CNS neurons.

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Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration.
Yang C, Wang X, Wang J, Wang X, Chen W, Lu N, Siniossoglou S, Yao Z, Liu K. Yang C, et al. Neuron. 2020 Jan 22;105(2):276-292.e5. doi: 10.1016/j.neuron.2019.10.009. Epub 2019 Nov 27. Neuron. 2020. PMID: 31786011 Free PMC article.

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Greasing the Wheels of Regeneration

Affiliations

Greasing the Wheels of Regeneration

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