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Editorial
. 2020 Jan 23;55(1):1902327.
doi: 10.1183/13993003.02327-2019. Print 2020 Jan.

Single cell analysis of human lung development: knowing what mesenchymal cells are and what they may be

Jennifer M S Sucre  1   2 , James Hagood  3   4
Affiliations
Editorial

Single cell analysis of human lung development: knowing what mesenchymal cells are and what they may be

Jennifer M S Sucre et al. Eur Respir J. .
No abstract available

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Conflict of interest statement

Conflict of interest: J.M.S. Sucre has nothing to disclose. Conflict of interest: J. Hagood has nothing to disclose.

Figures

FIGURE 1
FIGURE 1
Schematic overview of single cell RNA sequencing and of the human lung. Single cell suspensions were made from human lungs at 11.5 and 18.5 weeks of gestation, with a total of >3000 cells analysed with a detection rate of 2000–3000 genes per cell. Analysis of the transcriptomics allows for clustering of cells, identifying 10 clusters with corresponding cluster marker genes. Within the mesenchymal cell population, several subpopulations were identified, including pericytes, endothelial cells, a large population of non-specific human lung progenitors and two distinct populations of ACTA2-positive cells, airway smooth muscle cells and vascular smooth muscle cells.
See this image and copyright information in PMC

Comment on

References

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