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Meta-Analysis
. 2020 Jan 23;10(1):1075.
doi: 10.1038/s41598-019-56530-8.

A meta-analysis of the efficacy of HAART on HIV transmission and its impact on sexual risk behaviours among men who have sex with men

Ying Jiang  1 , Shu Su  2 , Yan Borné  3
Affiliations
Meta-Analysis

A meta-analysis of the efficacy of HAART on HIV transmission and its impact on sexual risk behaviours among men who have sex with men

Ying Jiang et al. Sci Rep. .

Abstract

Evidence showed preventive impacts of the highly active antiretroviral therapy (HAART) on the Human Immunodeficiency Virus (HIV) transmission amomg heterosexual population, however, that is of deficit among men who have sex with men (MSM). The aim was to systematically examine the efficacy of HAART on HIV transmission and the association between the HAART initiation and unprotected anal intercourse (UAI) in MSM population. Three electronic databases were fully searched for articles published in peer-reviewed journals between 1996 and 2017. Of 1616 identified articles, fifteen articles were eligible for meta-analyses. The summary incidence rate (IR) of HIV was 6.63/100 person-year (95%CI 2.06-11.20/100 person-year)(p = 0.004). The pooled per-contact rate (PCR) of HIV was 0.42% (95% CI 0.21-0.63%)(p < 0.05). The HAART initiation (vs non-HAART) was not associated with engaging in UAI, with odds ratio (OR) 1.09 (95% CI 0.90-1.34)(p > 0.05). In the stratified analysis, participants with no less than 6 months recall period was slightly more likely to engage in UAI (OR 1.32; 95% CI 1.01-1.74)(p < 0.05). It indicated that HAART has potential efficacy on reducing infectivity of HIV positive individuals in anal intercourses. The relationship between the HAART initiation and UAI was not significant and may be influenced by some social-demographic factors. Consistent condom use and education on safe sex among MSM are crucial.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
The forest plot of pooled estimate of IR, 100 person-year, in the era of HAART.
Figure 2
Figure 2
The forest plot of pooled estimate of per-contact rate (%) in the era of HAART.
Figure 3
Figure 3
The forest plot of pooled estimates of association between HAART and UAI.
Figure 4
Figure 4
PLASMA flow chat of literature search.
See this image and copyright information in PMC

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