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Randomized Controlled Trial
. 2020 May;30(5):2955-2963.
doi: 10.1007/s00330-019-06503-2. Epub 2020 Jan 23.

Refining the criteria for immediate total-body CT after severe trauma

Kaij Treskes  1 , Teun P Saltzherr  2 , Michael J R Edwards  3 , Benn J A Beuker  4 , Esther M M Van Lieshout  5 , Joachim Hohmann  6 , Jan S K Luitse  7 , Ludo F M Beenen  8 , Markus W Hollmann  9 , Marcel G W Dijkgraaf  10 , J Carel Goslings  7   11 ; REACT-2 study group
Collaborators, Affiliations
Randomized Controlled Trial

Refining the criteria for immediate total-body CT after severe trauma

Kaij Treskes et al. Eur Radiol. 2020 May.

Abstract

Objectives: Initial trauma care could potentially be improved when conventional imaging and selective CT scanning is omitted and replaced by immediate total-body CT (iTBCT) scanning. Because of the potentially increased radiation exposure by this diagnostic approach, proper selection of the severely injured patients is mandatory.

Methods: In the REACT-2 trial, severe trauma patients were randomized to iTBCT or conventional imaging and selective CT based on predefined criteria regarding compromised vital parameters, clinical suspicion of severe injuries, or high-risk trauma mechanisms in five trauma centers. By logistic regression analysis with backward selection on the 15 study inclusion criteria, a revised set of criteria was derived and subsequently tested for prediction of severe injury and shifts in radiation exposure.

Results: In total, 1083 patients were enrolled with median ISS of 20 (IQR 9-29) and median GCS of 13 (IQR 3-15). Backward logistic regression resulted in a revised set consisting of nine original and one adjusted criteria. Positive predictive value improved from 76% (95% CI 74-79%) to 82% (95% CI 80-85%). Sensitivity decreased by 9% (95% CI 7-11%). The area under the receiver operating characteristics curve remained equal and was 0.80 (95% CI 0.77-0.83), original set 0.80 (95% CI 0.77-0.83). The revised set retains 8.78 mSv (95% CI 6.01-11.56) for 36% of the non-severely injured patients.

Conclusions: Selection criteria for iTBCT can be reduced from 15 to 10 clinically criteria. This improves the positive predictive value for severe injury and reduces radiation exposure for less severely injured patients.

Key points: • Selection criteria for iTBCT can be reduced to 10 clinically useful criteria. • This reduces radiation exposure in 36% of less severely injured patients. • Overall discriminative capacity for selection of severely injured patients remained equal.

Keywords: Diagnostic imaging; Multidetector computed tomography; Multiple trauma; Whole-body imaging; Wounds and injuries.

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Conflict of interest statement

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

References

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