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. 1977 Jan;11(1):167-70.
doi: 10.1128/AAC.11.1.167.

Nalidixic acid-induced protein alterations in Escherichia coli

L Chao

Nalidixic acid-induced protein alterations in Escherichia coli

L Chao. Antimicrob Agents Chemother. 1977 Jan.

Abstract

The effect of nalidixic acid on pulse-labeled protein patterns was analyzed by sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis. The drug was found to alter protein patterns in a drug-sensitive strain but not in the isogenic drug-resistant strain of Escherichia coli. The drug-induced alteration of protein patterns was demonstrated by the appearance of some and the disappearance of other pulse-labeled peptides elicited by the drug.

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References

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